Sterile, single-use intra-articular hyaluronic acid gels for viscosupplementation in osteoarthritis and joint disorders. Four grades, developed and manufactured by SKY Biotechnology.
Intraarticular implant gels are injectable viscoelastic devices used to supplement the synovial fluid of joints affected by osteoarthritis and degenerative disorders. By supporting lubrication and shock absorption, they are intended to improve joint mobility and comfort. SkyVisc covers four grades on a common concentration range of 10–30 mg/mL: SkyVisc Pure (sodium hyaluronate alone), SkyVisc + (with L-proline), SkyVisc GGP (with L-proline, glycine and N-acetyl glucosamine) and SkyVisc Cross (the cross-linked grade) — three linear gels and one cross-linked, from a single source. As the flagship line of SKY Biotechnology, these products are developed and produced in-house.
Four grades of intra-articular hyaluronic acid gel — three linear, one cross-linked.
Highly purified sodium hyaluronate with no additives. Linear gel. Pre-filled syringe from 1 to 5 mL, in concentrations from 10 to 30 mg/mL.
Hyaluronic acid with L-proline, an amino acid that is a structural component of collagen. Linear gel. Pre-filled syringe (1–5 mL) or flacon (5 or 10 mL), in concentrations from 10 to 30 mg/mL.
Hyaluronic acid with L-proline, glycine and N-acetyl glucosamine — the constituents behind the GGP name (Glucosamine, Glycine, Proline). Linear gel. Pre-filled syringe (1–5 mL) or flacon (5 or 10 mL), in concentrations from 10 to 30 mg/mL.
Highly purified cross-linked hyaluronic acid of bacterial origin. Cross-linking bonds the polymer chains into a network that maintains its shape longer and slows disintegration. One injection per treatment. Pre-filled syringe (1–5 mL), 10 to 30 mg/mL.
| SkyVisc Pure | SkyVisc + | SkyVisc GGP | SkyVisc Cross | |
|---|---|---|---|---|
| Hyaluronic acid | 10 – 30 mg/mL | 10 – 30 mg/mL | 10 – 30 mg/mL | 10 – 30 mg/mL |
| Concentrations | 10 / 14 / 15 / 20 / 24 / 25 / 30 mg/mL | 10 / 14 / 15 / 20 / 24 / 25 / 30 mg/mL | 10 / 14 / 15 / 20 / 24 / 25 / 30 mg/mL | 10 / 14 / 15 / 20 / 24 / 25 / 30 mg/mL |
| Additional components | — | L-proline | L-proline, glycine, N-acetyl glucosamine | — |
| Bonding | Linear | Linear | Linear | Cross-linked |
| Syringe | 1 / 2 / 2.5 / 3 / 4 / 5 mL | 1 / 2 / 2.5 / 3 / 4 / 5 mL | 1 / 2 / 2.5 / 3 / 4 / 5 mL | 1 / 2 / 2.5 / 3 / 4 / 5 mL |
| Flacon | — | 5 / 10 mL | 5 / 10 mL | — |
| Formulation | Sodium hyaluronate in buffer (sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium chloride) — with L-proline in SkyVisc +; with L-proline, glycine and N-acetyl glucosamine in SkyVisc GGP. | |||
All SkyVisc grades: sterile viscoelastic solution, single use. Shelf life: 2 years. Storage: 2–25 °C — no cold chain required. CE marked.
Per the Instructions for Use. Intended for use by qualified healthcare professionals.
SkyVisc Pure is a sterile, single-use intra-articular implant gel whose active component is highly purified sodium hyaluronate of bacterial fermentation origin, supplied as a linear, non-cross-linked solution with no additives. It addresses the loss of synovial fluid viscoelasticity seen in osteoarthritis and degenerative joint disease: by restoring lubrication and shock absorption between the articular surfaces it is intended to reduce friction, relieve pain and support range of motion. SkyVisc Pure is offered in seven concentrations from 10 to 30 mg/mL in pre-filled syringes of 1 to 5 mL, is CE marked, and is developed and manufactured in-house under an ISO 13485 certified quality management system, with a two-year shelf life at 2–25 °C and no cold chain requirement.
Component-level view of the SkyVisc range. Refer to the Instructions for Use for the full intended purpose, contraindications and warnings.
| Component | Concentration | Clinical advantage | Certification |
|---|---|---|---|
| Sodium hyaluronate, bacterial fermentation origin | 10 – 30 mg/mL in seven steps: 10 / 14 / 15 / 20 / 24 / 25 / 30 mg/mL | Supplements depleted synovial fluid, restoring lubrication and shock absorption between articular surfaces | CE marked · ISO 13485 certified QMS |
| Phosphate buffer: sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium chloride | Isotonic carrier, common to all grades | Matches the physiological environment of the joint space and carries the hyaluronate at injectable viscosity | CE marked · ISO 13485 certified QMS |
| L-proline, in SkyVisc + | Added to the buffer of the 10 – 30 mg/mL formulation | An amino acid that is a structural constituent of collagen, added alongside the hyaluronate | CE marked · ISO 13485 certified QMS |
| L-proline, glycine and N-acetyl glucosamine, in SkyVisc GGP | Added to the buffer of the 10 – 30 mg/mL formulation | The three constituents behind the GGP name: Glucosamine, Glycine, Proline, delivered with the hyaluronate in one injection | CE marked · ISO 13485 certified QMS |
| Cross-linked sodium hyaluronate, in SkyVisc Cross | 10 – 30 mg/mL, cross-linked network | Cross-linking bonds the polymer chains into a network that holds its shape longer and slows disintegration, allowing one injection per treatment | CE marked · ISO 13485 certified QMS |
| Presentation and storage, all grades | Syringe 1 / 2 / 2.5 / 3 / 4 / 5 mL; flacon 5 or 10 mL for SkyVisc + and GGP | Two-year shelf life at 2 – 25 °C with no cold chain, which simplifies distribution in warm-climate markets | CE marked · ISO 13485 certified QMS |
Common questions from distributors and clinicians about the SkyVisc range.
In a linear gel the hyaluronate chains are not chemically bonded to one another, so the gel behaves as a viscous solution and is cleared from the joint relatively quickly. Cross-linking bonds the chains into a three-dimensional network, which holds its shape longer and slows disintegration. SkyVisc Pure, SkyVisc + and SkyVisc GGP are linear grades; SkyVisc Cross is the cross-linked grade and is given as one injection per treatment. All four share the same 10 to 30 mg/mL concentration range, so the choice is a question of bond structure and intended duration rather than of dose.
Grade selection follows the condition of the joint, the intended duration of effect and the viscosity required, and remains a matter of clinical judgement under the Instructions for Use. SkyVisc Pure contains hyaluronate alone and is the reference grade. SkyVisc + adds L-proline. SkyVisc GGP adds L-proline, glycine and N-acetyl glucosamine. SkyVisc Cross changes the bond structure itself rather than the additive package.
No. Every SkyVisc grade is stored between 2 and 25 degrees Celsius with a two-year shelf life, so no refrigerated transport or storage is needed. For distributors this removes cold chain cost and risk, which matters in warm-climate and long-lead-time markets.
GGP refers to the three constituents added to the hyaluronic acid in that grade: Glucosamine, Glycine and Proline. Precisely, SkyVisc GGP contains sodium hyaluronate with L-proline, glycine and N-acetyl glucosamine.
SkyVisc is developed and produced in-house by SKY Biotechnology at its own facility in Pendik, Istanbul, Turkiye, under an ISO 13485 certified quality management system. It is the flagship line of the company, which exports to more than fifty countries.
Technical specifications, regulatory documentation and catalogs are available to qualified partners on request.
Product information is provided for healthcare professionals, distributors and business partners and does not constitute medical advice. Availability, specifications and regulatory status may vary by country.